PROBIOTICS ROLE ON IMPROVING MALNUTRITION IN BOTH UNDER- AND OVERWEIGHT CHILDREN: A NARRATIVE REVIEW
DOI:
https://doi.org/10.63953/jisn.v3i3.54Keywords:
Probiotics, Pediatric malnutrition, Undernutrition, Obesity, Gut microbiotaAbstract
Background: Malnutrition in children exists at both ends of the spectrum, undernutrition and overnutrition, each with significant health consequences. Probiotics, live microorganisms that confer health benefits when administered in adequate amounts, are being explored as potential interventions through their ability to modulate gut microbiota, enhance nutrient absorption, and regulate immune function. Methods: A narrative review of literatures published between 2004 and 2025 was conducted, covering randomized trials, meta-analyses, and reviews involving probiotics interventions in children. Seventeen key studies were categorized by nutritional status (undernutrition and overnutrition), pediatric health outcomes, and nutritional insights. These studies synthesized and cited into this scientific narration. Results: In undernourished children, probiotics improved weight gain, reduced anemia, enhanced immune responses, and lowered respiratory infection incidence, particularly in low-resource settings. In overweight/obese children, certain Lactobacillus and Bifidobacterium strains improved BMI z-scores and metabolic health. Broader pediatric data support condition-specific benefits of probiotics in gastrointestinal and allergic diseases. Mechanistic evidence highlights bioactive molecules, immune modulation, micronutrient bioavailability, and gut barrier integrity as key pathways. Conclusions: Probiotics have context-specific benefits for pediatric malnutrition, with the strongest evidence in infection reduction and modest growth improvement in undernourished populations. Their role in pediatric obesity is promising but less defined. Strain specificity, dose, and duration remain critical determinants of efficacy, and further high-quality trials are needed.
References
Black RE, Victora CG, Walker SP, Bhutta ZA, Christian P, de Onis M, et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013;382(9890):427-451. doi:10.1016/S0140-6736(13)60937-X.
WHO. Malnutrition. 2023. Available from: https://www.who.int/news-room/fact-sheets/detail/malnutrition
Sahoo K, Sahoo B, Choudhury AK, Sofi NY, Kumar R, Bhadoria AS. Childhood obesity: causes and consequences. J Family Med Prim Care. 2015;4(2):187-192. doi:10.4103/2249-4863.154628.
Reilly JJ, Kelly J. Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int J Obes. 2011;35(7):891-898. doi:10.1038/ijo.2010.222.
FAO/WHO. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Rome: FAO/WHO; 2001.
Thomas DW, Greer FR, American Academy of Pediatrics Committee on Nutrition, American Academy of Pediatrics Section on Gastroenterology, Hepatology, and Nutrition. Probiotics and prebiotics in pediatrics. Pediatrics. 2021;147(6):e2021051485. doi:10.1542/peds.2021-051485.
Morales F, Montserrat-de la Paz S, Leon MJ, Rivero-Pino F. Effects of malnutrition on the immune system and infection and the role of nutritional strategies regarding improvements in children’s health status: a literature review. Nutrients. 2024;16(1):1. doi:10.3390/nu16010001.
Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491-502. doi:10.1038/nrgastro.2017.75.
Faradisa RR, Retnaningsih R, Alfitri R. The impact of probiotic yogurt supplementation on weight gain among preschool children: Evidence from an early childhood education setting in Indonesia. J Bimbingan Konseling Terapan. 2025;9(2):217-226. doi:10.30598/bkt.v9i2.19677.
Onubi OJ, Poobalan AS, Dineen B, Marais D, McNeill G. Effects of probiotics on child growth: a systematic review. J Health Popul Nutr. 2015;34:8. doi:10.1186/s41043-015-0010-4.
Adi AC, Kusharto CM, Marliyati SA. The effect of probiotic biscuit on faecal microbiota in malnourished children. Sains Malaysiana. 2022;51(12):4185-4195. doi:10.17576/jsm-2022-5112-25.
Matsuyama M, Harb T, David M, Davies PSW, Hill RJ. Effect of fortified milk on growth and nutritional status in young children: a systematic review and meta-analysis. Public Health Nutr. 2017;20(7):1214-1225. doi:10.1017/S1368980016003189.
Kartjito MS, Yosia M, Wasito E, Soloan G, Agussalim AF, Basrowi RW. Defining the relationship of gut microbiota, immunity, and cognition in early life—A narrative review. Nutrients. 2023;15(12):2642. doi:10.3390/nu15122642.
Paiandeh M, Jafari-Vayghan H, Hashemi R, Jafari-Vayghan V, Mirghafourvand M, Ghavami A, et al. The effect of probiotic, prebiotic, and synbiotic supplements on anthropometric measures and respiratory infections in malnourished children: A systematic review and meta-analysis. BMC Pediatr. 2024;24:702. doi:10.1186/s12887-024-05179-y.
Balás RB, Molnár D, Decsi T, Kennedy K, Martin CR, Péter S, et al. Prebiotics, probiotics, and synbiotics: A research hotspot for pediatric obesity. Nutrients. 2023;15(13):2973. doi:10.3390/nu15132973.
Quak SH. Role of probiotics and nutrition in the management of chronic inflammatory bowel disease in children. Singapore Med J. 2013;54(4):183-184. doi:10.11622/smedj.2013069.
Schneider R, Sant’Anna A. Using probiotics in paediatric populations. Paediatr Child Health. 2022;27(8):482-491. doi:10.1093/pch/pxac087.
Barkhidarian B, Roldos L, Iskandar MM, Saedisomeolia A, Kubow S. Probiotic supplementation and micronutrient status in healthy subjects: a systematic review of clinical trials. Nutrients. 2021;13(9):3001. doi:10.3390/nu13093001.
Linda A, Rahmawati N, Dewi IA, Putri YD, Nugraheni AY, Wijayanti R, et al. The impact of bioactive molecules from probiotics on child health: A comprehensive review. J Funct Foods. 2024;112:105028. doi:10.1016/j.jff.2024.105028.
Nawaz A, Nazir MI, Suleria HAR, Farooq F, Ayoub M, Baloch MH, et al. Nutritional and health potential of probiotics: A review. Appl Food Res. 2021;1(2):100016. doi:10.1016/j.afres.2021.100016.
Pasiak TF, Wiguna T, Sekartini R, Surapsari J, Sundjaya T, Wasito E, et al. The narrative review of recent studies in understanding the relationship between gut (microbiota)-brain axis, nutrition and cognitive function. World Nutr J. 2023;6(S2):30–40.
Kadim M, Masita BM. The importance of gut health in early life for long-term health. World Nutr J. 2022;5(S2):1–8. doi:10.25220/wnj.v05.s2.0001.
Sundjaya T, Djuwita R, Adisasmita AC, Tanjung C, Massi N, Fikri B, et al. Gut microbiome changes among undernutrition and stunting infants and children under 2 years: A scoping review. Open Public Health J. 2024;17(1). doi:10.2174/1874944502417010001.
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